Effects of flunixin meglumine, recombinant bovine somatotropin and/or human chorionic gonadotropin on pregnancy rates in Nelore cows

In cattle, fertilization rates can reach 100% [1–3] whereas the rates of live births after a single insemination are only 53% [4]. There are reports indicating that the majority of the reproductive losses during gestation occur between Days 8 and 16 of pregnancy [2,5]. During maternal recognition of pregnancy, at approximately Day 16 in cattle, the conceptus secretes molecules that signal to the endometrium to block prostaglandin F2  lpha (PGF2
) synthesis, preventing luteolysis [6,7]. Therefore, pharmacological strategies aiming to inhibit the synthesis of PGF2
are used to reduce embryonic mortality.

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